Ayşe Sözen Usluer graduated from the Faculty of Economics and Administrative Sciences at Marmara University in 1997, majoring in Business Administration. She was awarded with the degree of Master of Science in History of International Relations at the London School of Economics and Political Sciences in 2003. She completed her PhD in Political Science at İhsan Doğramacı Bilkent University in 2016.

Sözen Usluer worked as a foreign policy advisor (2003-2010) and held positions as Advisor at the Ministry of Foreign Affairs (2010-2011) and at the Ministry of EU Affairs (2011-2014). By November 2014, she was appointed as the Head of International Relations Department of the Presidency of the Republic of Türkiye.

She was the Ambassador of Türkiye to the Sultanate of Oman from August 1st, 2018 to December 31st, 2022.

She was İstanbul Representative of the Ministry of Foreign Affairs from January 15th, 2023 to 30th August 2026.

She is Permanent Representative of the Republic of Türkiye to the United Nations at Geneva since September 9th, 2026.

Sözen Usluer is married with two daughters.